Protocols (with DOIs)

Scored Surveys

View Scoring Protocol

Cognitive Function

View Cognitive Function Protocol

Imaging (MRI)

  1. Anatomic Measures dx.doi.org/10.17504/protocols.io.n92ld5yw9v5b/v1
  2. Perfusion Arterial Spin Labeling dx.doi.org/10.17504/protocols.io.n92ld667xg5b/v1
  3. Diffusion Weighted Imaging dx.doi.org/10.17504/protocols.io.6qpvrkopolmk/v1
  4. White Matter Intensities dx.doi.org/10.17504/protocols.io.n2bvjebwngk5/v1
  5. Rest-State Resting-State Functional Magnetic Resonance Imaging dx.doi.org/10.17504/protocols.io.81wgbnp41gpk/v1

Labs & Biomarkers

  1. APOE4 genotyping [DOI]: dx.doi.org/10.17504/protocols.io.n92ldzo68v5b/v1
  2. Milliplex Assay [DOI]: dx.doi.org/10.17504/protocols.io.n2bvj8rkbgk5/v1
  3. AD Biomarkers [DOI]: dx.doi.org/10.17504/protocols.io.bp2l6dop5vqe/v1
Citation Policy
Data collection and sharing for the Precision Aging Network (PAN) is funded by the National Institute on Aging (National Institutes of Health Grant “Closing the Gap Between Cognitive Health Span and Human Lifespan” (U19AG065169)).
MindCrowd Data
MindCrowd® is a web-based cognitive testing platform hosted at The Translational Genomics Research Institute (TGen). Initially funded through TGen and private donors in 2013 it grew to over 800,000 users across the globe. MindCrowd® is Project 1 of the Precision Aging® Network grant and serves not only as an entryway to the Healthy Minds for Life (Project 2) study but also affords participants opportunities for other ancillary studies.

For purposes of sharing data, we are including complete case data on a set of demographics data (age, sex, race/ethnicity) and two scored cognitive function tests, the paired associates learning test and simple visual reaction time test (svRT or attention test). We also include other user-provided health information that is included at the time the cognitive function tests were taken (note these variables may contain missing information).

A manuscript that describes the history of MindCrowd® and Precision Aging® Network more broadly can be found in a Gerontology editorial (https://doi.org/10.1159/000548488).

This data are included in a single data table as an Excel file through the research portal.

Available (N=364810)

Age

364810 (100%)

Sex

364810 (100%)

Race/Ethnicity

364810 (100%)

Handedness

357829 (98.1%)

Highest Level of Education Completed

363808 (99.7%)

Attention Test (svRT)

364810 (100%)

Paired Associates Test

364810 (100%)

Number of Daily Medications

357777 (98.1%)

No Chronic Conditions

277812 (76.2%)

Depression/Anxiety

277812 (76.2%)

Chronic Stress

277812 (76.2%)

Stroke

277812 (76.2%)

Alzheimers

277812 (76.2%)

Brain Disease

277812 (76.2%)

Loss of Consciousness

277812 (76.2%)

Memory Problems

277812 (76.2%)

Seizures

277812 (76.2%)

Parkinson’s Disease

277812 (76.2%)

Sleep Problems

277812 (76.2%)

Type I Diabetes

277812 (76.2%)

Type II Diabetes

277812 (76.2%)

Hypertension

277812 (76.2%)

Heart Disease

277812 (76.2%)

Smoking

277812 (76.2%)

Cancer

277812 (76.2%)

Data Dictionary

View MindCrowd Data Dictionary

Healthy Minds for Life Data

Healthy Minds for Life (HML) is the in-depth in-person longitudinal cohort project (Project 2) of the Precision Aging® Network. Data are collected from four sites: University of Arizona, Emory University, Johns Hopkins University and the University of Miami.

Many of the data collected in this study were summarized in a manuscript in Frontiers in Aging Neuroscience (https://doi.org/10.3389/fnagi.2019.00128). Additionally, manuscript that describes the history and details of the HML cohort and how it fits into the Precision Aging® Network more broadly we recommend a Gerontology editorial on the topic (https://doi.org/10.1159/000548488).

With the exception of the full MindCrowd® dataset, all data tables described on this website describe data from HML participants.

Other Data Tables
There are many health history, medications, demographic and biometrics data that have been collected both online (through MindCrowd) and in at in-person visits (Healthy Minds for Life). Some demographics (like age) are different from these two demographics tables because of the time between online sign-up to MindCrowd and recruitment into Healthy Minds for Life, we suggest using Healthy Minds for Life demographics (age, sex, etc.) as these are the closest in time to other data collected in person.

  1. Healthy Minds for Life Demographics
  2. Healthy Minds for Life Eligibility
  3. Medications and Health Intake
  4. Mind Crowd Demographics (includes some health history variables)
  5. Biometrics Data

 

Available (N=764)

Age

764 (100%)

Sex

764 (100%)

Race/Ethnicity

764 (100%)

Handedness

758 (99.2%)

Highest Level of Education Completed

764 (100%)

Attention Test (svRT)

764 (100%)

Paired Associates Test

764 (100%)

Number of Daily Medications

753 (98.6%)

Health Intake

764 (100%)

Mind Crowd Demographics (includes some health history variables)

726 (95.0%)

Medications and Health Intake

764 (100%)

Biometrics Data

763 (99.9%)

Healthy Minds for Life Eligibility

764 (100%)

These data can be found in the HML Demographics, HML Eligibility, Health Intake, MindCrowd Demographics, and Biometrics

Data Dictionary

View the HML Demographics Data Dictionary

Note: The Health Intake data table contains information about medications. We created a variable “dsc_meds_label_1” which is a derived variable using “hif_meds_1” variable and “hif_meds_oth_1” variable that should be used when the “meds_label_1” is missing.

Carotid Ultrasound
Each of the 4 sites was equipped with a Terason uSmart 3300 NexGen Ultrasound system with a 15L4A MHz uSmart Linear Array Transducer or alternative ultrasound systems with a 10-15MHz linear array transducer and a pre-set vascular protocol.

The mean and maximum intima-media thickness (IMT) of the near and the far walls of both right and left common carotid, carotid bifurcation, and internal carotid arteries are measured in the plaque-free segments. Doppler was used for measuring blood flow velocities in examination performed on the right and left common carotid, (CCA) internal (ICA) and external carotid arteries (ECA) for quick assessment of general extracranial hemodynamic status.

These data are located in the Carotid Ultrasound data table

Available (N=764)

Velocity Data

288 (37.7%)

Intima-Media Thickness (IMT) Data

194 (25.39%)


Standard Operating Procedures


Data Dictionary

View Carotid Ultrasound Data Dictionary

Cognitive Function
There are 4 paper scored tests and 5 computer captured cognitive tests.

Paper Tests

  1. Rey Auditory Verbal Learning Test (AVLT)
  2. Montreal Cognitive Assessment (MoCA)
  3. North American Adult Reading Test (NAART) Instructions
  4. North American Adult Reading Test (NAART) Answer Key
  5. Patient Health Questionnaire-9 (PHQ-9)

Online Tests

  1. Verbal Paired Associate Learning (associative memory)
  2. Simple and Choice Reaction Time (information processing speed)

Three are executive functioning tasks

  1. Keep Track Task (updating/working memory)
  2. Flanker Task (inhibition)
  3. Letter Number Task (set shifting)
[Protocol: dx.doi.org/10.17504/protocols.io.14egnyqw6v5d/v1]

Participant level results from these tests can be found in data tables with the test names.

Available (N=764)

AVLT

763 (99.87%)

MoCA

762 (99.74%)

NAART

762 (99.74%)

PHQ-9*

763 (99.87%)

Flanker Task

653 (85.5%)

Keep Track Task

587 (76.8%)

Letter Number Task

598 (78.3%)

Simple and Choice Reaction Time

618 (80.9%)

Verbal Paired Associate Learning

631 (82.6%)

*PHQ-9 is a depression screening tool

Data Dictionary

View Cognitive Function Data Dictionary

Imaging (MRI)
There are 7 data tables with processed MRI data.

  1. Anatomic Measures (using freesurfer)
  2. Perfusion Arterial Spin Labeling
  3. Diffusion Weighted Imaging
  4. Resting-State Functional Magnetic Resonance Imaging Cortical-Cerebellar
  5. Resting-State Functional Magnetic Resonance Imaging Whole Brain
  6. Resting-State Functional Magnetic Resonance Imaging Intra-Regional
  7. White Matter Hyperintensities

Available (N=764)

Anatomic Measures

700 (91.6%)

Perfusion Arterial Spin Labeling

671 (87.8%)

Diffusion Weighted Imaging

671 (87.8%)

Resting-State Functional Magnetic Resonance Imaging
Cortical-Cerebellar

672 (88%)

Resting-State Functional Magnetic Resonance Imaging Whole
Brain

672 (88%)

Resting-State Functional Magnetic Resonance Imaging
Intra-Regional

672 (88%)

White Matter Hyperintensities

692 (90.6%)

The data tables for these data can be found here (in order): MRI Anatomic Measures; MRI Perfusion ASL; MRI Diffusion Imaging; Resting State fMRI corticocereb; Resting State fMRI wholebrain; Resting State fMRI; and White Matter Hyperintensities

Data Dictionary

View the Imaging (MRI) Data Dictionary

Protocols

There are 5 protocols associated with these data

  1. Anatomic Measures dx.doi.org/10.17504/protocols.io.n92ld5yw9v5b/v1
  2. Perfusion Arterial Spin Labeling dx.doi.org/10.17504/protocols.io.n92ld667xg5b/v1
  3. Diffusion Weighted Imaging dx.doi.org/10.17504/protocols.io.6qpvrkopolmk/v1
  4. White Matter Intensities dx.doi.org/10.17504/protocols.io.n2bvjebwngk5/v1
  5. Rest-State Resting-State Functional Magnetic Resonance Imaging dx.doi.org/10.17504/protocols.io.81wgbnp41gpk/v1
Labs & Biomarkers
Currently we have 7 data tables containing labs and biomarkers:

  1. DNA methylation: Horvath, Altum, and DunedinPACE clocks
  2. TaqMan APOE4 genotyping for SNPs rs7412 and rs429358
  3. Polygenetic Risk Scores
  4. MILLIPLEX® Human Cytokine/Chemokine/Growth Factor Panel A – Immunology Multiplex Assay
  5. AD Biomarkers (Simoa Neuro 4-Plex E and Human pTau-181 Assays)
  6. Blood Chemistry (Sonora Quest Laboratory)
  7. NULISAseq Disease Panel 1

Available (N=764)

AD Plasma Biomarkers

628 (82.2%)

APOE4 Status

445 (58.25%)

Epigenetic Clocks

428 (56.02%)

Millipore Cytokine Assay

661 (86.52%)

NULISA Seq CNS Disease Panel

569 (74.48%)

Polygenic Risk Scores

445 (58.25%)

Sonora Quest Blood Chemistries

645 (84.42%)

Data tables include Epigenetic Clocks, APOE4, Polygenetic Risk Scores, Millipore Cytokine Assay, AD Plasma Biomarkers, Sonora Quest Blood Chemistries, and NULISAseq

Data Dictionary

View the Labs & Biomarkers Data Dictionary

Protocols

There are 3 protocols associated with these assays

  1. APOE4 genotyping [DOI]: dx.doi.org/10.17504/protocols.io.n92ldzo68v5b/v1
  2. Milliplex Assay [DOI]: dx.doi.org/10.17504/protocols.io.n2bvj8rkbgk5/v1
  3. AD Biomarkers [DOI]: dx.doi.org/10.17504/protocols.io.bp2l6dop5vqe/v1
Non-Invasive Technologies
These data are captured using non-invasive technology (sound, video, sweat and wearable devices). The processing of these data typically involves machine learning and novel techniques.

There are 4 categories of data

  1. Cortisol (palmer sweat Direct Analysis in Real Time Mass Spectrometry (DART-MS))
  2. Sensor/Wearable (Garmin)
  3. Frailty (Upper Extremity Function, video)
  4. Language and Speech Tasks (sound files)

Available (N=764)

Garmin

439 (57.46%)

Language Speech Task

753 (98.56%)

UEF Frailty

687 (89.92%)

Cortisol

607 (79.45%)

These data are found in the Cortisol, LabFront Garmin, UEF Frailty, and Language Speech Task data tables

Data Dictionary

View Wearables Data Dictionary

Surveys

Scored Surveys

There are a total of 15 surveys, with 7 scored instruments

Data collection forms for the scored surveys are included in the Scoring Protocol.

Scored Survey Forms

Available (N=764)

Anxiety

568 (74.3%)

QPAR

566 (74.1%)

SWLS

616 (80.6%)

Sleep

564 (73.8%)

Social Stressors

604 (79.1%)

Social Support

611 (80%)

Stress

616 (80.6%)

[Scoring Protocol here DOI: dx.doi.org/10.17504/protocols.io.q26g7nwy9lwz/v1]

These surveys are included in the HML Scored Survey data table and raw data for these surveys can be found in the data tables named like: Perceived Stress Raw Data

Data Dictionary (Scored Surveys)

View the Scored Surveys Data Dictionary

Remaining surveys are participant reported and can be found in the data tables with the following names:

  • Socioeconomic Survey
  • Subjective English Survey
  • Health Medical Survey
  • Family History Survey
  • Diet Survey
  • Covid Survey
  • Brain Disease Survey
  • ADL Survey

Raw Surveys

Available (N=764)

ADL

610 (79.8%)

Anxiety

568 (74.3%)

Brain Disease

557 (72.9%)

Covid

557 (72.9%)

Diet

609 (79.7%)

FHAD

627 (82.1%)

Health Medical

558 (73%)

QPAR

566 (74.1%)

SES

619 (81%)

SWLS

616 (80.6%)

Sleep

564 (73.8%)

Social Stressors

604 (79.1%)

Social Support

611 (80%)

Stress

616 (80.6%)

Subjective English

638 (83.5%)

Data Dictionary (Raw Surveys)

View the Raw Surveys Data Dictionary

Survey Forms (Raw Data)

Protocols (with DOIs)

Scored Surveys

View Scoring Protocol

Cognitive Function

View Cognitive Function Protocol

Imaging (MRI)

  1. Anatomic Measures dx.doi.org/10.17504/protocols.io.n92ld5yw9v5b/v1
  2. Perfusion Arterial Spin Labeling dx.doi.org/10.17504/protocols.io.n92ld667xg5b/v1
  3. Diffusion Weighted Imaging dx.doi.org/10.17504/protocols.io.6qpvrkopolmk/v1
  4. White Matter Intensities dx.doi.org/10.17504/protocols.io.n2bvjebwngk5/v1
  5. Rest-State Resting-State Functional Magnetic Resonance Imaging dx.doi.org/10.17504/protocols.io.81wgbnp41gpk/v1

Labs & Biomarkers

  1. APOE4 genotyping [DOI]: dx.doi.org/10.17504/protocols.io.n92ldzo68v5b/v1
  2. Milliplex Assay [DOI]: dx.doi.org/10.17504/protocols.io.n2bvj8rkbgk5/v1
  3. AD Biomarkers [DOI]: dx.doi.org/10.17504/protocols.io.bp2l6dop5vqe/v1